Laboratory of Biochemistry & Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science
In April 2018, I established the Akira Sato Research Group at the Tokyo University of Science, Faculty of Pharmaceutical Sciences. The focus of our research is cancer cell death and anticancer drug resistance. By determining the mechanisms underlying these phenomena, we hope to contribute to the development of cancer therapies. We are currently looking for graduate and undergraduate students who are willing to learn and think on this research subject. If you are interested, we can show you around our laboratory, which is always open to visitors.
Cell death can, depending on the morphological and biochemical features of the cell itself, be broadly characterized as either necrosis or apoptosis. Anticancer drugs trigger death in cancer cells, and if we can elucidate the mechanisms by which this occurs, then we can contribute to the development of new anticancer drugs. Moreover, cancer cells can use various mechanisms to acquire resistance to anticancer drugs. By understanding the mechanisms underlying cancer cell “death” and “resistance” to anticancer agents, our research group aims to find new molecular targets and to develop nucleic acids and low-molecular-weight compounds specific to these targets as novel cancer treatments.
Junior Associate Professor
Akira SATO, Ph.D.
Undergraduate school: Tohoku Pharmaceutical University, Japan
Graduate school: Okayama University, Japan (Prof. Yusuke Wataya)
Cell death (Necrosis, Apoptosis), Anticancer drug resistance, Non-coding RNA (MicroRNA, Long non-coding RNA), Exosome
1. Analysis of molecular mechanisms in two-types cancer cell death, necrosis and apoptosis
2. Analysis of anticancer drug resistance mechanisms in cancer cells
3. Analysis of cell-death mode in human retinal pigment epithelium (RPE) cells